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TNTU

TNTU is a coupling reagent for peptide synthesis in SPPS and LPPS. Used for acylation of a peptide side chain.

CAS:125700-73-4

Synonym:2-(endo-5-norbornene-2,3-dicarboxylimide)-1,1,3,3-tetramethyluronium tetrafluoroborate

Properties

Purity

≥98.0%

Molecular Formula

C14H20BF4N3O3

Molecular Weight

365.13 [gr/mol]

Appearance

White to off-white crystalline powder

Storage Conditions

Store in a cool and dry place (20oC)

Applications

  • Recent studies show TNTU is a suitable reagent for ε-Amino acylation of Lys  – modification process for GLP-1 agonist synthesis
  • TNTU is a reagent used for solution and solid phase peptide synthesis.

Studies

  • Highly Selective Lysine Acylation in Proteins Using a Lys-His Tag Sequenceacids and hybrid peptides
    C. Kofoed, S. Wu, K. K. Sørensen, T. Treiberg, J. Arnsdorf, S. P. Bjørn, T. L. Jensen, B. G. Voldborg, M. B. Thygesen, K. J. Jensen, S. Schoffelen, Chem. Eur. J. 202228, e202200147
    https://doi.org/10.1002/chem.202200147
  • Recent development of peptide coupling reagents in organic synthesis. So-Yeop Han, Young-Ah Kim
    Tetrahedron, Volume 60, Issue 11,2004, Pages 2447-2467,
    https://doi.org/10.1016/j.tet.2004.01.020.
  • Peptide Coupling Reagents, More than a Letter Soup
    A. El-Faham and F. Albericio. Chem. Rev., 2011, 111, 6557-6602.
  • Thermal Stability Assessment of Peptide Coupling Reagents Commonly Used in Pharmaceutical Manufacturing
    Jeffrey B. Sperry*, Christopher J. Minteer, JingYa Tao, Rebecca Johnson, Remzi Duzguner, Michael Hawksworth, Samantha Oke, Paul F. Richardson, Richard Barnhart, David R. Bill, Robert A. Giusto, and John D. Weaver III
    Org. Process Res. Dev. 2018, 22, 9, 1262–1275

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