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TCTU is a Coupling reagent used for peptide solid-phase synthesis. Suitable for automatic multiple peptide synthesizers.

CAS: 330641-16-2

Synonym: O-(1H-6-Chlorobenzotriazol-1-yl)-1,1,3,3- tetramethyluronium tetrafluoroborate




Molecular Formula


Molecular Weight

355.53 [gr/mol]


White to off-white crystalline powder

Storage Conditions

Store in a cool and dry place (2-8oC)


  • TCTU shows better results when compared to TBTU.


  • Assessment of 6Cl-HOBt-based coupling reagents in solid-phase cyclopeptide synthesis
    G. Sabatino, M. C. Alcaro, M. de la Cruz Pozo-Carrero, M. Chelli. P. Rovero, A. M. Papini  Biopolymers, 2003.
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  • Amide bond formation: beyond the myth of coupling reagents
    E. Valeur and M. Bradley Chem. Soc. Rev., 2009, 38, 606-631.
  • Thermal Stability Assessment of Peptide Coupling Reagents Commonly Used in Pharmaceutical Manufacturing
    Jeffrey B. Sperry*, Christopher J. Minteer, JingYa Tao, Rebecca Johnson, Remzi Duzguner, Michael Hawksworth, Samantha Oke, Paul F. Richardson, Richard Barnhart, David R. Bill, Robert A. Giusto, and John D. Weaver III
    Org. Process Res. Dev. 2018, 22, 9, 1262–1275

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