TCFH

TCFH – a safe, affordable reagent for ester and difficult amide synthesis

CAS: 207915-99-9

Synonym: Chloro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate

Properties

Purity

≥98.0%

Molecular Formula

C5H12ClF6N2P

Molecular Weight

280.58 [gr/mol]

Appearance

White to off-white crystalline powder

Storage Conditions

Store in a cool and dry place (2-8oC)

Applications

TCFH as a reagent has several advantages beside being economical:
– Due to is high coupling potency, it might be used in reactions previously only accomplished using carbodiimide-mediated couplings, extending in this manner its application for the formation of esters, diacyl amides and acylation of non-reactive amines
– It is solid, reasonably stable compound, when stored around 0°C
– Using the widely available coupling additives the chemist can find optimal reagent ratio to balance between the product yield and the side reactions including epimerization.

Studies

  • TCFH – a safe, affordable reagent for ester and difficult amide synthesis
    Read Article

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