TCFH – a safe, affordable reagent for ester and difficult amide synthesis
Synonym: Chloro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate
White to off-white crystalline powder
Store in a cool and dry place (2-8oC)
– Due to is high coupling potency, it might be used in reactions previously only accomplished using carbodiimide-mediated couplings, extending in this manner its application for the formation of esters, diacyl amides and acylation of non-reactive amines
– It is solid, reasonably stable compound, when stored around 0°C
– Using the widely available coupling additives the chemist can find optimal reagent ratio to balance between the product yield and the side reactions including epimerization.