Skip to main content


TCEP-HCl, odorless, effective scavenger used in TFA cleavages of peptide resins, reduction of disulfide bind in proteins and peptides.


Synonym: Tris(2-carboxyethyl)phosphine hydrochloride




Molecular Formula

C9H15O6P · HCl

Molecular Weight

286.65 [gr/mol]


White to off-white crystalline powder

Storage Conditions

Store in a cool place


TCEP HCl  -scavenger in TFA cleavages of peptide resins. Disulfide bond-reducing agent in peptides and proteins.

  • Odorless reducing agent
  • Comparable with DTT effectivity
  • Stable – does not oxidize under exposure to air. Not reactive with protein functional groups. Stable in acidic aqueous solutions
  • Water soluble
  • TCEP, unlike some other reducing agents, doesn’t require removal prior to most applications



  • B. Dhayalan, K. Mandal, N. Rege, M. A. Weiss, S. H. Eitel, T. Meier, R. O. Schoenleber, S. B. H. Kent, Chem. Eur. J. 201723, 1709.

Request an Information or Quotation

Information Request

    Price Quote Request

      Skip to content