TCEP-HCl, odorless, effective scavenger used in TFA cleavages of peptide resins, reduction of disulfide bind in proteins and peptides.
Synonym: Tris(2-carboxyethyl)phosphine hydrochloride
C9H15O6P · HCl
White to off-white crystalline powder
Store in a cool place
- Odorless reducing agent
- Comparable with DTT effectivity
- Stable – does not oxidize under exposure to air. Not reactive with protein functional groups. Stable in acidic aqueous solutions
- Water soluble
- TCEP, unlike some other reducing agents, doesn’t require removal prior to most applications
- B. Dhayalan, K. Mandal, N. Rege, M. A. Weiss, S. H. Eitel, T. Meier, R. O. Schoenleber, S. B. H. Kent, Chem. Eur. J. 2017, 23, 1709.