TBDC HCl, Advanced Carbodiimide Coupling Agent for Peptide Synthesis in Aqueous and Green Solvents. Carbodiimide for minimal protection LPPS.
CAS:3082189-34-9
Synonym: 3-(((tert-butylimino)methylene)amino)-N,N-dimethylpropan-1-amine hydrochloride
Properties
Purity
≥98.0%
Molecular Formula
C9H21N4Cl3
Molecular Weight
220,75 [gr/mol]
Appearance
White to off-white crystalline powder
Storage Conditions
Store in a cool place
Applications
TBDC (3-(((tert-butylimino)methylene)amino)-N,N-dimethylpropan-1-amine) salts represent a new generation of water- and organic-solvent-compatible coupling agents for peptide bond formation. These next-generation CDIs overcome key limitations of traditional reagents like EDC·HCl and DIC, offering:
- Minimal protection synthesis compatible. No need for protecting groups on His, Trp, Ser, Tyr, Thr
- High conversion (>95%) and low racemization (L:D > 95:5)
- Compatible with green solvents: EtOAc, 2-MeTHF, GVL, DMC
- Suitable for both manual and automated synthesis
- Forms open-chain stable intermediates unlike EDC
TBDC salts enable highly efficient amide bond formation in solution-phase, solid-phase, and green chemistry processes, eliminating the need for histidine and tryptophan side-chain protection in many cases.
Studies
Application No 320701 CARBODIIMIDES FOR USE AS A COUPLING AGENT