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T-BEC® is a novel carbodiimide that outperforms DIC, and does not lead to HCN formation in the presence of OxymaPure. Its urea (TBEU) is highly soluble in DMF and most of the green and binary solvents.

CAS: 1433-27-8  

Synonym: 1-tert-Butyl-3-ethylcarbodiimide




Molecular Formula


Molecular Weight

126.20 [gr/mol]


Light yellow to colorless transparent liquid

Storage Conditions

Store in a cool and dry place (2-8oC)


  • T-BEC® carbodiimide surpasses DIC in terms of efficiency, making it a more effective coupling reagent.
  • In contrast to DIC, T-BEC® does not generate an oxadiazole side-product when used with OxymaPure, eliminating the formation of HCN.
  • T-BEC® urea (TBEU) demonstrates exceptional solubility in commonly employed peptide coupling solvents like DMF or NMP, as well as future green/ binary solvents. This reduces the risk of equipment clogging during manufacturing.
  • T-BEC® employs the same coupling protocols as other carbodiimides, ensuring easy integration into existing chemical processes.
  • T-BEC® is recognized as a greener coupling reagent, offering environmentally friendly properties and contributing to sustainable chemical practices.


  • tert-Butylethylcarbodiimide as an Efficient Substitute for Diisopropylcarbodiimide in Solid-Phase Peptide Synthesis: Understanding the Side Reaction of Carbodiimides with OxymaPure Srinivasa Rao Manne, Damilola Caleb Akintayo, Omar Luna, Ayman El-Faham, Beatriz G. de la Torre, and Fernando Albericio Organic Process Research & Development 2022 26 (10), 2894-2899       DOI: 10.1021/acs.oprd.2c00220
  • Amide Formation: Choosing the Safer Carbodiimide in Combination with OxymaPure to Avoid HCN Release Srinivasa Rao Manne, Omar Luna, Gerardo A. Acosta, Miriam Royo, Ayman El-Faham, Gyorgy Orosz, Beatriz G. de la Torre, and Fernando Albericio Organic Letters 2021 23 (17), 6900-6904    DOI: 10.1021/acs.orglett.1c02466 Read Article
  • Synthesis of the Antimicrobial Peptide Murepavadin Using Novel Coupling Agents García-Gros, Júlia, Yolanda Cajal, Ana Maria Marqués, and Francesc Rabanal. 2024.  Biomolecules 14, no. 5: 526. Read Article


T-BEC® carbodiimide and OxymaPure® for Sustainable SPPS

Srinivasa Rao Manne, Hlobisile Nzama, Oleg Marder, Beatriz G. de la Torre, Fernando Albericio

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