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T-Bec® is a novel carbodiimide that outperforms DIC, and does not lead to HCN formation in the presence of OxymaPure. Its urea (TBEU) is highly soluble in DMF and most of the green and binary solvents.

CAS: 1433-27-8  

Synonym: 1-tert-Butyl-3-ethylcarbodiimide




Molecular Formula


Molecular Weight

126.20 [gr/mol]


Light yellow to colorless transparent liquid

Storage Conditions

Store in a cool and dry place (2-8oC)


  • T-Bec® carbodiimide is more efficient than DIC.
  • Contrary to DIC, T-Bec® does not form an oxadiazole side-product in the presence of OxymaPure that does not lead to the formation of HCN.
  • Urea of T-Bec® (TBEU) is very soluble in most commonly employed peptide coupling solvents, such as DMF or NMP, and future green binary solvents which prevent clogging of the manufacturing equipment.
  • T-Bec® uses the same coupling protocols as other carbodiimides.
  • It is considered the greener coupling reagent.


  • tert-Butylethylcarbodiimide as an Efficient Substitute for Diisopropylcarbodiimide in Solid-Phase Peptide Synthesis: Understanding the Side Reaction of Carbodiimides with OxymaPureSrinivasa Rao Manne, Damilola Caleb Akintayo, Omar Luna, Ayman El-Faham, Beatriz G. de la Torre, and Fernando AlbericioOrganic Process Research & Development 2022 26 (10), 2894-2899       DOI: 10.1021/acs.oprd.2c00220
  • Amide Formation: Choosing the Safer Carbodiimide in Combination with OxymaPure to Avoid HCN ReleaseSrinivasa Rao Manne, Omar Luna, Gerardo A. Acosta, Miriam Royo, Ayman El-Faham, Gyorgy Orosz, Beatriz G. de la Torre, and Fernando AlbericioOrganic Letters 2021 23 (17), 6900-6904    DOI: 10.1021/acs.orglett.1c02466 Read Article

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