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QCD, a stable, safe, easy-to-use, environmentally friendly, affordable water soluble carbodiimide ideally suited for liquid phase peptide synthesis.

CAS: 6179-57-3

Synonym: 1-Ethyl-(3-dimethylaminopropyl)carbodiimide methyl tosylate; 1-[3-(trimethylammonium)propyl]-3-ethylcarbodiimide 4-methylbenzenesulfonate




Molecular Formula

C8H17N3. SO3 C7H7

Molecular Weight

326,4 [gr/mol]


White to off-white crystalline powder

Storage Conditions

Store in a cool place


  • Its nearest analog, 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC.HCL ) is known to be unstable in organic solvents prone to cyclize under basic conditions. Due to the different structure, QCD cannot cyclize yielding higher conversion efficiencies, the use of less coupling reagents.
  • QCD, in combination with OxymaPure, does not generate hydrogen cyanide, an extremely toxic material that is observed with DCC or DIC.
  • Use of OxymaPure as a synthesis additive results in improved yields and product quality.
  • QCD, being a quaternary ammonium compound can be washed out from the organic extraction phase either by acidic or basic water phase. Both the coupling reagent and the formed urea prefer the water phase
  • Not toxic, not irritate skin and eyes.


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