QCD® , a stable, safe, easy-to-use, environmentally friendly, affordable water soluble carbodiimide ideally suited for liquid phase peptide synthesis.
CAS: 6179-57-3
Synonym: 1-Ethyl-(3-dimethylaminopropyl)carbodiimide methyl tosylate; 1-[3-(trimethylammonium)propyl]-3-ethylcarbodiimide 4-methylbenzenesulfonate
Properties
Purity
≥98.0%
Molecular Formula
C9H20N3·SO3C7H7
Molecular Weight
341,47 [gr/mol]
Appearance
White to off-white crystalline powder
Storage Conditions
Store in a cool place
Applications
- Its nearest analog, 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC.HCL ) is known to be unstable in organic solvents prone to cyclize under basic conditions. Due to the different structure, QCD®cannot cyclize yielding higher conversion efficiencies, the use of less coupling reagents.
- QCD®, in combination with OxymaPure, does not generate hydrogen cyanide, an extremely toxic material that is observed with DCC or DIC.
- Use of OxymaPure as a synthesis additive results in improved yields and product quality.
- QCD®, being a quaternary ammonium compound can be washed out from the organic extraction phase either by acidic or basic water phase. Both the coupling reagent and the formed urea prefer the water phase
- Not toxic, not irritate skin and eyes.
Studies
Nzama, H., Manne, S. R., Marder, O., Orosz, G., de la Torre, B. G., & Albericio, F. (2024). Unveiling the quaternary carbodiimide symphony: harmonizing green chemistry in peptide synthesis. Green Chemistry Letters and Reviews, 17(1). https://doi.org/10.1080/17518253.2024.2392826
Posters
TBDC® and QCD®: Novel water soluble carbodiimides for TAG assisted LPPS and minimal protection synthesis
Oleg Marder1, Srinivasa Rao Manne2, Hlobisile Nzama2, Beatriz G. de la Torre2, Fernando Albericio2, Alessandra Tolomelli3, Dario Corbisiero3, Lucia
Ferrazzano3, Nicola Patrian3 ,and Walter Cabri3