PyHOPO® is a novel and highly efficient coupling reagent with an exceptionally low racemization rate.
CAS: 3080680-87-8
Synonym:((2-oxopyridin-1(2H)-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafulorophosphate
Properties
Purity
≥99.0%
Molecular Formula
C17H28F6N4O2P2
Molecular Weight
496.37 [gr/mol]
Appearance
White crystalline powder
Storage Conditions
Store in a cool and dry place (2-8oC)
Applications
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Enables peptide coupling with no detectable racemization, even with sensitive amino acids like His and Cys.
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Shows comparable coupling efficiency to PyBOP.
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Offers a safer alternative to benzotriazole-based reagents.
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Its phosphonium nature prevents premature chain termination (unlike uronium salts)
Studies
- Synthesis and Structural Confirmation of PyHOPO and Its Applicability in Racemization Reduction in Solid-Phase Peptide Synthesis,
Kwazi Masuku, Anamika Sharma, Sikabwe Noki, Sizwe Zamisa, Ayman El-Faham, Beatriz G. de la Torre, Fernando Albericio,Tetrahedron Letters, Volume 160, 2025, 155520,https://doi.org/10.1016/j.tetlet.2025.155520