Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product. May be used in place of BOP in peptide synthesis without loss of coupling efficiency.
Synonym: (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
White to off-white powder
Store in a cool and dry place (2-8oC)
- Coupling reactions are rapid, being nearly complete within a few minutes.
- Especially useful for cyclization steps for the activation of hindered amino acid.