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DIC has the advantage over N,N’-Dicyclohexyl­carbodiimide in solid phase peptide syntheses that the urea by-product is more soluble in organic solvents and hence more readily separated from the polymer support.

CAS: 693-13-0

Synonym: N,N’-Diisopropylcarbodiimide




Molecular Formula


Molecular Weight

126.20 [gr/mol]


Colorless to very faintly brownish-yellow liquid

Storage Conditions

Store in cool place.
Store under inert gas. Moisture sensitive.


  • Used in combination with OxymaPure® in peptide synthesis.


  • OxymaPure/DIC: An Efficient Reagent for the Synthesis of a Novel Series of 4-[2-(2-Acetylaminophenyl)-2-oxo-acetylamino] Benzoyl Amino Acid Ester Derivatives  A. El-Faham, Z. A. Marhoon, A. Abdel-Megeed, and F. Albericio Molecules, 2013, 18, 14747-14759.
  • Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences I. Coin, M. Beyermann, and M. Bienert Nature Protocols, 2017, 2, 3247-3256.
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  • Thermal Stability Assessment of Peptide Coupling Reagents Commonly Used in Pharmaceutical Manufacturing
    Jeffrey B. Sperry*, Christopher J. Minteer, JingYa Tao, Rebecca Johnson, Remzi Duzguner, Michael Hawksworth, Samantha Oke, Paul F. Richardson, Richard Barnhart, David R. Bill, Robert A. Giusto, and John D. Weaver III
    Org. Process Res. Dev. 2018, 22, 9, 1262–1275

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