Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product. May be used in place of BOP in peptide synthesis without loss of coupling efficiency.
Synonym: (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
White to off-white powder
Store in a cool and dry place (2-8oC)
- Coupling reactions are rapid, being nearly complete within a few minutes.
- Especially useful for cyclization steps for the activation of hindered amino acid.
- PyBOP®: A new peptide coupling reagent devoid of toxic by-product
J. Coste, D. Le-Nguyen, B. Castro Tetrahedron Lett., 1990, 31, 205-208.
- Thermal Stability Assessment of Peptide Coupling Reagents Commonly Used in Pharmaceutical Manufacturing
J.B. Sperry, C.J. Minteer, J.Y. Tao, R. Johnson, R. Duzguner, Michael Hawksworth, Samantha Oke, Paul F. Richardson, R. Barnhart, D.R. Bill, R.A. Giusto, and J.D. Weaver III,
Org. Process Res. Dev., 2018, 22, 9, 1262–1275