TPTU

TPTU applied in large scale applications for the synthesis of Pharmaceuticals, in particular in situations where sensitive functionality is present on the coupling partners, and as a consequence, mild reaction conditions are required.

CAS: 125700-71-2

Synonym: O-(2-Oxo-1(2H)pyridyl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

Properties

Purity

≥90.0%

Molecular Formula

C10H16BF4N3O2

Molecular Weight

297.06 [gr/mol]

Appearance

White to off-white crystalline

Storage Conditions

Store in a cool and dry place (2-8oC)

Applications

  • TPTU together with HOBt have been used in coupling reactions, leading to the impressive outcomes of couplings free of racemization, thus are the reagents of choice for segment condensations.
  • TPTU has been applied in the preparation of activated Fmoc-His(Trt)-OH, reducing the racemization. Application of these coupling methods improved the quality of the crude product significantly, thus, this contribution represents a further step towards an optimal strategy for the incorporation of His. This method helps to overcome the problem of racemization for the His residue, a prerequisite for the synthesis of large peptides and proteins.

Studies

  • Coupling Methods for Fmoc-His(Trt)-OH Resulting in Minimal Racemization
    M. Mergler, F. Dick, and Th. Vorherr BACHEM AG, Hauptstr., 144, CH-4416.
  • Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals
    J. R. Dunetz, J. Magano, and G. A. Weisenburger Org. Process Res. Dev., 2016, 20, 140−177.

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