PyBOP

Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product. May be used in place of BOP in peptide synthesis without loss of coupling efficiency.

CAS: 128625-52-5

Synonym: (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

Properties

Purity

≥99.0%

Molecular Formula

C18H28N6.OP.PF6

Molecular Weight

520.39 [gr/mol]

Appearance

White to off-white powder

Storage Conditions

Store in a cool and dry place (2-8oC)

Applications

  • Coupling reactions are rapid, being nearly complete within a few minutes.
  • Especially useful for cyclization steps for the activation of hindered amino acid.

Studies

  • PyBOP®: A new peptide coupling reagent devoid of toxic by-product
     J. Coste, D. Le-Nguyen, B. Castro Tetrahedron Lett., 1990,  31, 205-208.
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