COMU® features optimal properties as a peptide coupling reagent. In addition to its high and fast coupling efficiency, it shows very low or non-existent tendencies for racemization. COMU is a registered patent of Luxembourg Bio Technologies (No. 101784522/8,524,898).
COMU® is a registered patent of Luxembourg Bio Technologies Ltd., and we are the exclusive manufacturers.
Synonym: (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate
White to off-white crystalline powder
Store in a cool and dry place (2-8oC)
- Epimerization during fragment coupling appears to be lessened with COMU than with HOBt or HATU.
- COMU is fully compatible with microwave-assisted peptide synthesis.
- COMU is very soluble in most commonly employed peptide coupling solvents, such as DMF or NMP, which makes it ideally suited for solid phase peptide synthesis.
- It is equally attractive for solution phase synthesis since by-products formed by COMU are water-soluble and can be separated by simple extraction.
- A color change during the reaction allows visual or colorimetric reaction monitoring.
- COMU can be used with nearly identical protocols that apply for common coupling reagents such as HBTU, TBTU, PyBOP, or HATU.
- It is considered the greener coupling reagent.
- It is used in some Canadian schools.
- COMU: A Safer and More Effective Replacement for Benzotriazole-Based Uronium Coupling Reagents.
A. El-Faham, R. S. Funosas, R. Prohens, and F. Albericio Chem. Eur. J., 2009, 15, 9404–9416.
- COMU: A third generation of uronium-type coupling reagents
A. El-Faham and F. Albericio J. Pept. Sci. 2010, 16, 6–9.
- Microwave heating in solid-phase peptide synthesis
Tofteng, L. Malik, S. L. Pedersen, K. K. Sørensen, K. J. Jensen Chem. Soc. Rev., 2012, 41, 1826–1844.
- Efficient and Controllably Selective Preparation of Esters Using Uronium-Based Coupling Agents
J. K. Twibanire and T. B. Grindley Org. Lett. 2011, 13, 12, 2988–2991.