TCTU

TCTU is a Coupling reagent used for peptide solid-phase synthesis. Suitable for automatic multiple peptide synthesizers.

CAS: 330641-16-2

Synonym: O-(1H-6-Chlorobenzotriazol-1-yl)-1,1,3,3- tetramethyluronium tetrafluoroborate

Properties

Purity

≥98.0%

Molecular Formula

C11H15BClF4N5O

Molecular Weight

355.53 [gr/mol]

Appearance

White to off-white crystalline powder

Storage Conditions

Store in a cool and dry place (2-8oC)

Applications

  • TCTU shows better results when compared to TBTU.

Studies

  • Assessment of 6Cl-HOBt-based coupling reagents in solid-phase cyclopeptide synthesis
    G. Sabatino, M. C. Alcaro, M. de la Cruz Pozo-Carrero, M. Chelli. P. Rovero, A. M. Papini  Biopolymers, 2003.
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  • Amide bond formation: beyond the myth of coupling reagents
    E. Valeur and M. Bradley Chem. Soc. Rev., 2009, 38, 606-631.

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