DMT-Cl

Used in the coupling stage of nucleoside (hydroxyl protecting agent).

CAS: 40615-36-9

Synonym: 4,4′-Dimethoxytrityl chloride

Properties

Purity

≥99.5%

Molecular Formula

C6H5C(C6H4OCH3)2Cl

Molecular Weight

338.83 [gr/mol]

Appearance

Light pink color powder

Storage Conditions

Store in cool place

Applications

  • DMT is used as a super-labile protecting group for the thiol of Cys, showing  more labile features than the MethoxyTrityl (MMT).

Studies

  • Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA, and 2′-Amino-LNA Monomers
    A. Ries, R. Kumar, C. Lou, T. Kosbar, E. Vengut-Climent, P. T. Jørgensen, J. C. Morales, and J. Wengel J. Org. Chem. 2016, 81, 10845−10856.

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