DIC

DIC has the advantage over N,N’-Dicyclohexyl­carbodiimide in solid phase peptide syntheses that the urea by-product is more soluble in organic solvents and hence more readily separated from the polymer support.

CAS: 693-13-0

Synonym: N,N’-Diisopropylcarbodiimide

Properties

Purity

≥99.0%

Molecular Formula

C7H14N2

Molecular Weight

126.20 [gr/mol]

Appearance

Colorless to very faintly brownish-yellow liquid

Storage Conditions

Store in cool place.
Store under inert gas. Moisture sensitive.

Applications

  • Used in combination with OxymaPure® in peptide synthesis.

Studies

  • OxymaPure/DIC: An Efficient Reagent for the Synthesis of a Novel Series of 4-[2-(2-Acetylaminophenyl)-2-oxo-acetylamino] Benzoyl Amino Acid Ester Derivatives  A. El-Faham, Z. A. Marhoon, A. Abdel-Megeed, and F. Albericio Molecules, 2013, 18, 14747-14759.
  • Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences I. Coin, M. Beyermann, and M. Bienert Nature Protocols, 2017, 2, 3247-3256.
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