DIC has the advantage over N,N’-Dicyclohexylcarbodiimide in solid phase peptide syntheses that the urea by-product is more soluble in organic solvents and hence more readily separated from the polymer support.
Colorless to very faintly brownish-yellow liquid
Store in cool place.
Store under inert gas. Moisture sensitive.
- Used in combination with OxymaPure® in peptide synthesis.
- OxymaPure/DIC: An Efficient Reagent for the Synthesis of a Novel Series of 4-[2-(2-Acetylaminophenyl)-2-oxo-acetylamino] Benzoyl Amino Acid Ester Derivatives A. El-Faham, Z. A. Marhoon, A. Abdel-Megeed, and F. Albericio Molecules, 2013, 18, 14747-14759.
- Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences I. Coin, M. Beyermann, and M. Bienert Nature Protocols, 2017, 2, 3247-3256.