6-Cl-HOBt in NMP

Designed to limit epimerization and increase efficiency during peptide synthesis, 6-Cl-HOBt produces activated esters during amino acid coupling reactions. Luxembourg Bio Technologies is selling 6-Cl-HOBt in NMP solution to ensure easy of use and safe shipping.

CAS: 

Synonym: 6-Cl-Hydroxybenzotriazole in N-Methylpyrrolidine solution

Properties

Purity

Molecular Formula

C6H5N3OCl 

Molecular Weight

Appearance

Yellowish liquid

Storage Conditions

Store in a cool and dry place (2-8oC)

Applications

  • Additive to coupling reactions as a racemization suppressor.
  • Used in both solid-phase and solution-phase peptide synthesis.
  • Ready-for-use solution of 6-Cl-HOBt in NMP.
  • 15% or 20% solution made to customer’s specification
  • Can be shipped by air.

Advantages of using our 6-Cl-HOBt in NMP over the 6-Cl-HOBt as powder.

  • Ready to use material, no need to dissolve, shorten production cycle and reduce cost.
  • Worker is not exposed to irritating and allergenic properties of 6-Cl-HOBt powder.
  • Usage 6-Cl-HOBt in solution eliminate a risk of powder explosion at the working place.
  • Factory does not need to obtain a special permit from authorities for storage of flammable solids.
  • Can replace 6-Cl-HOBt powder in established processes – not considered as a change of production process.
  • 6-Cl-HOBt in NMP is produced  to highest quality standards.

Studies

  • E. Srebotnik, Kenneth E. Hammel Degradation of nonphenolic lignin by the laccase:1-hydroxybenzotriazole system Journal of Biotechnology 81 (2000) 179–188.
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  • Lai C. Chan and Brian G. Cox Kinetics of Amide Formation through Carbodiimide/N-Hydroxybenzotriazole (HOBt) Couplings J. Org. Chem. 2007, 72, 8863-8869.
    Read Article
  • M. Mali, M. G. Kumar, M. M. Katariya, H. N. Gopi HBTU mediated 1-hydroxybenzotriazole (HOBt) conjugate addition: synthesis and stereochemical analysis of β-benzotriazole N-oxide substituted γ-amino acids and hybrid peptides Org. Biomol. Chem.
    Read Article

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