Services

High Quality Ready-Made Activating Reagents

Pharmaceutical manufacturers throughout the world rely on our comprehensive, ready-made product selection. Certified by ISO 9001, we choose only the highest quality raw materials for manufacturing of activating reagents for peptide synthesis, as well as amide and ester bond formation.  New items are continuously being added to meet the needs of a growing and diversifying market.

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What is a good coupler from the industrial point of view?

Effective Coupling Reagent

• Works with high efficiency for a wide variety of peptide sequences.
• Works in stoichiometric quantities.
• Has a high conversion rate at room temperature.
• Works for both solution and solid-phase peptide synthesis.
• Is soluble in all the currently used solvents and can be used at high concentrations.
• Solutions are stable for several days at room temperature.
• Allows monitoring of coupling reagents.
• Shows few side reactions.
• Its secondary products after coupling can be completely removed by solvent extraction.

Cost-Effective Reagent

• Can Be Produced in Large Quantities
• Conventional raw material available.
• Technology is known and does not require installation of sophisticated equipment.
• Chemistry is adaptable for up-scaling.
• Raw material solvents and catalysts are safe for the producer.
• Effective waste management.
• Has a prolonged shelf-life at ambient conditions.

Safe for Producer, User, and Environment
• Material is not toxic, corrosive or self-reactive.
• The use of material does not result in formation of toxic by-products.
• Does not generate hazardous waste.
• Can be disposed with low pollution risk.

Not sure which is the right material for your specific needs? Just ask – we’ll be happy to help you decide on the product that best suits your requirements.

In addition, you are welcome to visit our “Studies” page to view our virtual library, where we tried to collect the most recent academic papers and posters from the latest conferences regarding products we offer.

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Quality Assurance

All our products are tested using our methods, which were internally developed to assure the best quality. Our ISO certified laboratory is equipped with up to date instruments and very professional team. All our methods are available for our customers on demand.

Each batch we produce comes with a certificate of analysis and a TSE/BSE statement issued by our Quality Assurance unit. We are fully equipped to develop a new methods to meet your needs.

In an effort to prolong shelf life, we test our products’ parameters two years following production, and samples of each production batch are stored for seven years, to ensure a reference point.
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Packaging and logistics

Packaging is an integral part of the overall quality of any finished product. We use polyethylene high density (HDPE) containers, which meet the international codes for transporting hazardous goods, based on UN recommendations; including ICAO/IATA for air transport, ADR/RID for railway and road transport, and IMO/IMDG for shipping. The transportation and subsequently storage and use issue, becomes critical for the reagents containing the imidazole ring benzotriazoles (HOBt), which according to recent studies has a relatively high sensitivity to friction, spark, and electrostatic discharge resulting in burning or explosion. Logistics and transportation department control material packed in appropriate containers should not exceed weight restrictions and appropriate labeling and documentation.

We provide non-returnable wooden pallets with heat treatment that comply with the ISPM15 standards.

We have 2 logistic partners in Europe and 1 in USA.

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Development and Commercialization of a Custom-Made Reagents

If your requirements demand a reagent that does not yet exist, we can make it happen. Using the finest raw materials, our highly experienced team of developers and manufacturers will work closely with you to create the exact product you need, swiftly and efficiently. Our skilled people can translate theoretical ideas in to practical  implementing and  facilitating  on going industrial production.

Why classic activators remain for decades in the market? 
Despite the presence of novel, highly effective coupling reagents, the classical activators have remained in the market for years. We could point out a few reasons to define this fact:
• Influence of the human factor, which includes inertness or unavailability of human recourses to test and evaluate new coupling systems.
• Marketing problem, when a manufacturing company or distributor could not identify and localize its potential target group and end users.
• Supply chain when the information about new products and application provided by developer or supplier does not always can find its addressee.
• Legal and secrecy issues do not always give the opportunity of knowledge exchange between peptide contract manufacturer and raw material producer.
• Role of existing regulation requirements. List of the reagents used in a synthesis and synthetic process and methods used in a synthesis, including the reagents and synthesis condition should come as a part of an Investigational New Drug application (IND) for Phase I study, of a NDA (New Drug Application) submitted to FDA at the completion of phase II clinical trial, and of a DMF (Drug Master File).

Today, the synthesis of peptide or protein based pharmaceutical drug requires up to 100 steps, the name of the game is “production cost” and the modern synthetic technologies play a central role in this battle. A thorough study of the mechanism in each method involving basic producer for logistic and technical support is a necessary term for the optimization of the coupling step of a new peptide drug and further up-scaling towards bulk  manufacturing.

Up-scaling from the bench and beyond requires from the manufacturer reevaluation of very critical parameters such as transportation, storage, user safety and waste management of raw materials and in particular coupling reagents. There are situations where reagents, convenient and handy in laboratory, become unmanageable by contract manufacturer when it comes to bulk peptide manufacturing. This may lead to production
downscaling and reevaluation of synthetic procedure.

The modern chemical laboratories are usually well equipped to provide environmental and personal protection to technicians and researchers from possible toxic effect of raw material. The situation becomes more complicated when it comes to industry. To protect the worker and the environment, special precautions should be taken by manufacturer. This includes special equipment for preventing dusty conditions at the time of reactor loading, personal protection which usually consists of protective suit, gloves, boots and full face mask with air breathing apparatus and requires additional training of personnel.

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Swift Sourcing of Rare and Hard-to-Find Materials

Using our strong global connections and log-term relationships with producers and suppliers, we will search the earth to obtain the materials you need. Our years of experience and in-depth field knowledge mean that the product you get will be of the highest quality, fully tested and backed by our personal guarantee.

We understand the risks global business entails. Our know-how comes from many years of international experience.  We will supply the best quality-to-price ratio for your existing products and/or new items.

Our Advantages

Clarity and Transparency

We are choosing an appropriate partner for your needs and saving your time and minimize the risk

Small quantities

Market research for future demands

We do a full product quality assessment

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Pilot and Scale-Up Projects

Looking to launch a new pilot project but don’t have a manufacturing plant of your own? Created a project in your lab but lack the facilities to scale it up? Luxembourg Bio Technologies works with two proven factories in Europe, running projects ranging from lab scale to multi liter reactors. Let us know your exact needs and we’ll be happy to put your project in motion.

We are working under NDA agreement and keep all confidential material, knowledge and sensitive information.

A pilot is a way of testing a theoretical model on a small-scale  level, in order to discover potential problems that otherwise would not be detected until full-scale deployment.

Why pilot and scale-up Projects are important?

  • Before investing in a large-scale project, testing its assumptions on a smaller scale can leave us better equipped to plan and execute for the larger scale deployment.
  • We can reduce the risk of propagating mistakes by detecting errors at the pilot stage.
  • The project team members can gain more experience before engaging in a more demanding project.
  • Pilots can be used to compare two or more similar solutions in order to find out which one works best.

Why choose us?

  • We are working with selected CMO for pilot projects
  • Our pilot team is very professional with huge experience in troubleshooting
  • Luxembourg Bio Technologies is using Multidisciplinary consultant’s desk all over the word to achieve storming synergy.
  • Helping in sourcing of high quality reagents in bulk quantities to reduce the production cost
  • Can offer a few different pilot plants to run the same project to accelerate knowledge accumulation.

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At Luxembourg Bio Technologies, we always go the extra mile to ensure that our customers are completely satisfied, with every order filled to their exact specifications and expectations. Moreover, we pride ourselves on the long-lasting relationships we nurture with each of our customers, partners and suppliers – so that together we can help bring the most advanced and innovative materials and drugs into existence.