HONB

HONB has been reported as the additive of choice for water solid-phase peptide synthesis (SPPS).

CAS: 21715-90-2

Synonym: N-Hydroxy-5-norbornene-2,3-dicarboxylic acid imide

Properties

Purity

≥98.0%

Molecular Formula

C9H9NO3

Molecular Weight

179.17 [gr/mol]

Appearance

White to off-white powder

Storage Conditions

Store in cool place

Applications

  • Active esters derived from hydroxamic acid, such as HONB, have also found broad application. The first were the O-phthalimido esters, which release a water-insoluble side product. However, these were soon replaced by the more versatile succinimido esters (OSu). The latter generate watersoluble N-hydroxysuccinimide, which is straightforward to remove from target peptides.

Studies

  • Solid-phase peptide synthesis in water using microwave-assisted heating
    A. S Galanis, F. Albericio, M. Grøtli Org. Lett.2009, 11(20), 4488-4491.

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