BOP

BOP, as other phosphonium salts, have the advantage of not yielding quinidinium by-products via reaction of the coupling reagent with amine.

CAS: 56602-33-6

Synonym: (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

Properties

Purity

≥99.0%

Molecular Formula

C12H22F6N6OP2

Molecular Weight

442.28 [gr/mol]

Appearance

White crystalline powder

Storage Conditions

Store in a cool and dry place (2-8oC)

Applications

  • The BOP reagent is introduced as HOBt derivative, which contains the racemization suppressant HOBt, avoiding epimerization and other side reactions that can take place with carbodiimide reagents.
  • Although it is an excellent coupling reagent, hexamethylphosphoramide (HMPA), a toxic compound is generated.

Studies

  • Large scale applications of amide coupling reagents for the synthesis of pharmaceuticals
    J. R. Dunetz, J. Magano, and G. A. Weisenburger Org. Process Res. Dev. 2016, 20, 140-177.

Request an Information or Quotation